the first, all spore, carotenoid rich, probiotic consortium formulation on the market.
MegaSporeBiotics a Practitioner-only product.
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We are more bacteria than human!
- 10 trillion human cells vs 100 trillion bacteria cells.
- There are over 1000 different species of commensal organisms in the GI tract out of 35,000 possible.
- Bacterial genes out number human genes 150 to 1 ( 25,000 human genes vs. 3.3 million microbial genes)
- No two individuals have the exact same composition – not even twins. Species level vast difference
- Disease is associated with a disruption to the ecology of the GI tract such as Crohn’s disease, IBS, asthma and even obesity.
- Pathogenic organisms are normal inhabitant of the GI tract such as H.pylori, staphylococcus, e.coli.
- We actually use bacterial DNA for our own metabolic functions.
What disrupts the population of probiotics in our gut?
- Birth via C-Section
- Baby formula instead of breast milk
- Antibiotic use, especially if take at a young age and always if not combined with probiotics.
- Anti-bacterial soap and hand sanitizers have a significant detrimental effect on the development of healthy GI flora.
Other Affects on the Microbiome
- Surgery , usually followed by antibitocs.
- Age, the older we get the more the microbiome declines.
- Food choices, the healthier the food choices the better the positive impact on our microbiome.
- Toxic substances, influence our gut microbiome. Fluoride in tap water, precooked foods, sodas, with ingredients such as artificial sweeteners, syrups.
- Prescription drugs, Tobacco, Alcohol
What kind of probiotics are required?
It’s important to note that the first part of the definition of a probiotic is that the microorganism has to be alive or it doesn’t fit the definition of a probiotic.
Studies by the Food Standards Agency has confirmed that more than 90 % of strains used in probiotic products today do not survive the gastric system. Thus, they are not “live microorganisms” and not probiotics.
A true probiotic has to naturally survive the gastric barrier – as MegaSporeBiotic ™ does.
- Must have a position in the microbiota – it’s important for a probiotic to be able to colonize well to afford its beneficial function. Without a spot for it, it will not be able to compete.
- Must have sufficient numbers to colonize and cause stimulation for benefit.
This is an important feature that is often overlooked. Probiotics work in large part by causing stimulation in the GI. But this stimulation can only occur if the amount of live microorganisms being administered exceeds the natural number of those same species that exist in the GI. This is a fundamental issue with most lactobacillus-and bifidobacterium- based probiotics. These strains naturally exist in the GI in numbers exceeding a trillion cells; thus supplementing in amounts even in the billions, doesn’t cause the necessary stimulation.
The strains found in MegaSporeBiotic exist in total numbers of a few million cells in the GI, thus supplementing in excess of 4 billion live cells causes massive stimulation of the GI.
, by evolution, should naturally occur in the environment (where they gain exposure to the host) and be stable both in the environment and GI tract. Ask yourself where did our Ancestors get their probiotics from? Certainly not from a health food store. They got it with the food from the earth (environment). So, any true probiotic should be found in the environment.
Survival of probiotics through gastric juices in the stomach, 20 min at pH 1-3
Summary: only 4 of 35 strains would survive to enter the large intestine and the survivors would have less than 50 % survival.
MegaSporeBiotic is the first, pharmaceutical grade probiotic formulation naturally designed to survive the harsh gastric environment and arrive at the site of action alive – ensuring full potency.
So, what’s nature’s design for supplemental probiotics?
- The most popular is Bacillus spores; also the most wildly studied and used probiotics outside of the supplement market.
- Bacillus spores were the first commercial probiotics. Were also the first prescription probiotics starting in 1958:
- Enterogermina (Sanofi-Aventis, Italy)
- Bacti-Subtil (Aventis, Pharma, France)
- Most widely used and well studied strains in humans are:
- Bacillus Subtilis
- Bacillus Licheniformis
- Bacillus Coagulans
- Bacillus Clausii
- Introducing – Patented Bacillus Indicus HU 36
Key Features of Bacterial Spores
- They form robust endospore and can withstand harsh temperatures, desiccation, low pH, gastric barriers, antibiotics, UV radiation, solvents, enzymes and even high pressures.
- They are found all over the environment (soil, vegetation, dust, rocks, aqua-environments, digestive systems of insects, marine life, mammals, etc)
- Spores remain dormant up to 50 years
- They colonize very effectively in the Human GI tract and have been found to colonize very effectively in the GI tract of several different animals.
- Are found as part of the normal human commensal flora.
- Long history of use in industries where efficacy is closely measured (pharma, agricultural)
- Extremely safe Use of probiotics are supported by evolution.
- Its use as a probiotic is evolutionarily supported – true commensal organism.
In spore forms they are transported from host to host / from the environment into the GI tract.
We don’t get the exposure to these spores as we should due to the sterile food supply.
The probiotics have 2 lifecycles / they can live outside the human host in the environment.
As soon as the spores get into the GI tract they understand where they are and they come out of the spore form and transform into vegetated, thriving cell.
Where do we get our probiotics from?
- All the lactobacillus from our mother when we pass through the birth canal as well as through the amnionic fluid, through core blood and from breast milk.
- Those species are not in the environment so humans are not designed to consume those species.
- Spores on the other hand are found all over in the environment
- Was developed by Dr. Simon Cutting, Ph.D
- The only dietary supplement probiotic that contains Bacillus Clausii – a strain tested for over 50 years.
- Contains 5 efficacious bacillus spore probiotics in the consortium – each strain is backed up by a history of use and by published science.
- Delivers over 4 billion live probiotic cells daily – a dose that matches and exceeds all prescription products of the same strains. The single most powerful spore probiotic formulation.
- Blended with a pre-biotic to enhance colonization.
- Spores produce a significant number of potent antibiotics that control bacterial over-growth in the GI tract
- Spores conduct competitive exclusion of pathogenic organisms to help maintain microbiota balance. They fight for space and nutrients to eliminate the invading species. Such as candida or c diff.
- Spores have the ability to increase the numbers of the important GI tract commensals, such as lactobacillus.
Immunemodulation means a down regulation when it’s over active or up regulation when it is under active.
- Bacillus probiotics has been shown to produce key enzymes that help the digestion of food products and alleviate bloating, cramping and discomfort. Enzymes like alpha-amylase, lactase, protease and lipase are improved with the use of Bacillus.
- Dysbiosis (i.e. the presence of harmful bacteria and the imbalance of good bacteria in the GI tract) is the main cause of digestive disorders and can be argued as being the root cause of most disease. Dysbiosis is also responsible for incomplete digestion of consumed foods. Studies have shown that Bacillus probiotics help prevent the growth of harmful bacteria and promotes the growth of beneficial bacteria – thus alleviating dysbiosis.
Key Nutrient Production
- Production of vitamins – Bacillus probiotics have been shown to produce important amounts of vitamin K and biotin in the large intestines. Absorption of these vitamins are high as they are produced at the sight of absorption.
- Bacillus also digests resistant starches and non-starch polysaccharides (is a major component of dietary fiber) to short-chain fatty acids, mainly acetate, propionate, and butyrate, which stimulates colonic blood flow and fluid and electrolyte uptake
- New Bacillus Indicus HU36 – produces high levels of carotenoids that are of the highest bioavailability.
Bacillus Subtilis HU58
- Widely used, safe and highly effective
- Produces over 12 affective antibiotics
- Makes nattokinase and vitamin K2
- Highly important for immune development and stimulation of the immune system
Bacillus Indicus HU36
- Potent immune stimulation
- Produces high levels of carotenoids – lycopene, axtaxanthin, beta-caroten, lutin.
- Produces quinols and vitamins
- The most effective antioxidants on the market.
- Most widely used probiotic drug in the world.
- Potent immune stimulator
- Antibiotic resistant for use during antibiotic treatment
- Produces antibiotic bacitracin.
- Produces protease for digestion and helps protein digestion.
- Produces whole spectrum of B vitamins and Folic acid.
- Very well studied and long history of use
- Very effective against IBS, Crohn’s.
- Produces L+ optical from of lactic acid
- Potent immune stimulation
Dose, unlike lactobacillus sp and bifidobacterium sp, bacillus spores are found in concentrations around 2 million cells in the gut.
With a dose of just over 4 billion live cells daily, megaspore offers a potent probiotic effect as the dose exceeds the endogenous species by 2000 times / highest on the market.
MegaSpore is both transient and a colonizer.
It is both, which is another unique aspect of these strains.
It is transient because it has about a 21-27 day life cycle in the digestive system. Each individual cell spends about that much time in the gut in various sections and tissues. During their time in the gut, they do attach and colonize.
They attach, they metabolize, they grow by binary fission and they alter the environment around themselves.
If you took just a single dose of Megaspore once, you will find those strains in your gut and stool samples for 21+ days. The digestive system is something like 30 ft long from end to end and it has the surface area of a professional tennis court, so this is a lot of ground to cover.
The strains have the unique ability to exist in various segments of the digestive tract and in various tissues; the mucosa and epithelium.
So when you consume a capsule, the cells move along through your digestive tract and colonize different locations. Some stay in the upper GI (small bowel), some go on to ascending colon, some to the transverse colon, some to the distal.
They attach there and start multiplying to build up their number.
But with that one does, they get fairly spread out, so additional doses are good as you do 2 things:
- You increase their numbers so they can cover more tissue and
- You get that continuous immune stimulation/modulation from the daily exposure to them. Especially in the Peyer’s patches. Peyer’s patches are organized lymphoid nodules usually found in the lowest portion of the small intestine and the ileum. They are important in immune surveillance and generate immune response within the mucosa.
Why do the bacteria leave the GI tract? They are programmed to leave the gut at some interval because it is crucial to their survival and spread. They use the environment to transfer from host to host. So they have to leave and enter back into the environment to find the next host. This is how they have spread all over the globe.
So they have it programmed in their DNA to re-sporulate and leave the body at some point. But they do leave behind some of their new cells, which will also leave about 21 days after they were created.
Nature has designed them to be consumed continuously as our ancestors did. That daily stimulation/modulation of our immune tissue by the spores is critical to immune function. Also keeping their numbers up in the gut is a big benefit to us.