Effects of combined prebiotic, probiotic, IgG and amino acid supplementation on the gut microbiome of patients with inflammatory bowel disease
This New Research Study was just published in Pubmed on 16 Sept 2022
The Total Gut Restoration (TGR) system includes spore-based probiotics, prebiotics and a combination of immunoglobulins and amino acids. Each of these supplements has individually shown benefits for the health of the gut microbiome. We assessed the effects of daily supplementation with all TGR system components over 5 days in a laboratory simulation of the human gastrointestinal tract. We used fecal samples from patients with inflammatory bowel disease to learn whether supplementation would result in any changes to the gut microbiome in these patients. We evaluated changes in the production of short-chain fatty acids (considered beneficial for gut health) and changes in the composition of the gut microbiome before and after 5 days of TGR supplementation. There were significant increases in short-chain fatty acid production and changes to the microbiome that are considered to be beneficial to human health. These findings demonstrate that daily TGR supplementation may facilitate beneficial changes to the gut microbiome of patients with inflammatory bowel disease.
IBD – Inflammatory bowel disease is a chronic inflammatory disease of the gut which includes Crohn’s disease and ulcerative colitis. People with those conditions suffer from abdominal pain, diarrhea, weight loss, blood in stool and fatigue. Globally about 6.8 million cases were known in 2017. Findings show that people with IBD have an imbalance of beneficial and pathogenic bacteria in the gut which is called dysbiosis.
The following paragraph will be of interest to you because it explains the function of Probiotics and Prebiotics which have been used in this study.
The Food Agricultural Organization/WHO have defined probiotics as “live microorganisms which when administered in adequate amounts confer a health benefit to the host”; these health benefits are believed to be the result of changes to the composition of the intestinal microbiome, suppression of pathogens, immunomodulation, and improvement of the gut intestinal barrier through stimulation of epithelial proliferation and differentiation [7,8]. Spore-forming probiotic species, including Bacillus spp., are well suited for use as probiotics because they are resistant to heat and desiccation and are stable over a wide range of pH values . The use of Bacillus probiotics is associated with increased levels of short-chain fatty acid (SCFA)-producing bacteria [10–12], improved quality of life in patients with irritable bowel syndrome , shortening of the duration of diarrhea and reduced incidence of hospitalization among patients with childhood acute diarrhea , a reduced concentration of lipid in the blood , a reduction in post-prandial dietary endotoxin, triglycerides and disease risk biomarkers  and antiobesity and antidiabetic properties . Given these beneficial associations, Bacillus spores are considered an attractive probiotic option. MegaSporeBiotic™ is an oral probiotic comprising five Bacillus spp. (Bacillus indicus HU36, Bacillus subtilis HU58, Bacillus coagulans SC208, Bacillus licheniformis SL307 and Bacillus clausii SC109). This product has been shown to significantly increase SCFA levels and increase the abundance of beneficial microbes such as Akkermansia muciniphila, Bifidobacteria spp. and Firmicutes after repeated administration (vs the control period) when evaluated in the in vitro simulator of the human intestinal microbial ecosystem (SHIME®) model using fecal samples from healthy donors .
please read the rest of the study here which explains further the benefits of the products used in this study…..