Probiotic MegaSporeBiotic

MegaSporeBiotic                                                        MegaSporeBiotic

the first, all spore, carotenoid rich, probiotic consortium formulation on the market.

MegaSporeBiotics a Practitioner-only product.

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We are more bacteria than human!
  • 10 trillion human cells vs 100 trillion bacteria cells.
  • There are over 1000 different species of commensal organisms in the GI tract out of 35,000 possible.
  • Bacterial genes out number human genes 150 to 1 ( 25,000 human genes vs. 3.3 million microbial genes)
  • No two individuals have the exact same composition – not even twins. Species level vast difference
  • Disease is associated with a disruption to the ecology of the GI tract such as Crohn’s disease, IBS, asthma and even obesity.
  • Pathogenic organisms are normal inhabitant of the GI tract such as H.pylori, staphylococcus, e.coli.
  • We actually use bacterial DNA for our own metabolic functions.
What disrupts the population of probiotics in our gut?
  • Birth via C-Section
  • Baby formula instead of breast milk
  • Antibiotic use, especially if take at a young age and always if not combined with probiotics.
  • Anti-bacterial soap and hand sanitizers have a significant detrimental effect on the development of healthy GI flora.
Other Affects on the Microbiome
  • Surgery , usually followed by antibitocs.
  • Age, the older we get the more the microbiome declines.
  • Food choices, the healthier the food choices the better the positive impact on our microbiome.
  • Toxic substances, influence our gut microbiome. Fluoride in tap water, precooked foods, sodas, with ingredients such as artificial sweeteners, syrups.
  • Prescription drugs, Tobacco, Alcohol
What kind of probiotics are required?

It’s important to note that the first part of the definition of a probiotic is that the microorganism has to be alive or it doesn’t fit the definition of a probiotic.

Studies by the Food Standards Agency has confirmed that more than 90 % of strains used in probiotic products today do not survive the gastric system. Thus, they are not “live microorganisms” and not probiotics.

A true probiotic has to naturally survive the gastric barrier – as MegaSporeBiotic ™ does.

  • Must have a position in the microbiota – it’s important for a probiotic to be able to colonize well to afford its beneficial function. Without a spot for it, it will not be able to compete.
  • Must have sufficient numbers to colonize and cause stimulation for benefit.

This is an important feature that is often overlooked. Probiotics work in large part by causing stimulation in the GI. But this stimulation can only occur if the amount of live microorganisms being administered exceeds the natural number of those same species that exist in the GI. This is a fundamental issue with most lactobacillus-and bifidobacterium- based probiotics. These strains naturally exist in the GI in numbers exceeding a trillion cells; thus supplementing in amounts even in the billions, doesn’t cause the necessary stimulation.

The strains found in MegaSporeBiotic exist in total numbers of a few million cells in the GI, thus supplementing in excess of 4 billion live cells causes massive stimulation of the GI.

            • Supplemented Probiotics

, by evolution, should naturally occur in the environment (where they gain exposure to the host) and be stable both in the environment and GI tract.  Ask yourself where did our Ancestors get their probiotics from? Certainly not from a health food store. They got it with the food from the earth (environment). So, any true probiotic should be found in the environment.

Survival of Probiotics

Survival of probiotics through gastric juices in the stomach, 20 min at pH 1-3

Summary: only 4 of 35 strains would survive to enter the large intestine and the survivors would have less than 50 % survival.

MegaSporeBiotic is the first, pharmaceutical grade probiotic formulation naturally designed to survive the harsh gastric environment and arrive at the site of action alive – ensuring full potency.

Indications

So, what’s nature’s design for supplemental probiotics?

  • The most popular is Bacillus spores; also the most wildly studied and used probiotics outside of the supplement market.
  • Bacillus spores were the first commercial probiotics. Were also the first prescription probiotics starting in 1958:
  • Enterogermina (Sanofi-Aventis, Italy)
  • Bacti-Subtil (Aventis, Pharma, France)
  • Most widely used and well studied strains in humans are:
  • Bacillus Subtilis
  • Bacillus Licheniformis
  • Bacillus Coagulans
  • Bacillus Clausii
  • Introducing – Patented Bacillus Indicus HU 36
Key Features of Bacterial Spores
  • They form robust endospore and can withstand harsh temperatures, desiccation, low pH, gastric barriers, antibiotics, UV radiation, solvents, enzymes and even high pressures.
  • They are found all over the environment (soil, vegetation, dust, rocks, aqua-environments, digestive systems of insects, marine life, mammals, etc)
  • Spores remain dormant up to 50 years
  • They colonize very effectively in the Human GI tract and have been found to colonize very effectively in the GI tract of several different animals.
  • Are found as part of the normal human commensal flora.
  • Long history of use in industries where efficacy is closely measured (pharma, agricultural)
  • Extremely safe Use of probiotics are supported by evolution.
  • Its use as a probiotic is evolutionarily supported – true commensal organism.
In spore forms they are transported from host to host / from the environment into the GI tract.
We don’t get the exposure to these spores as we should due to the sterile food supply.

The probiotics have 2 lifecycles / they can live outside the human host in the environment.

As soon as the spores get into the GI tract they understand where they are and they come out of the spore form and transform into vegetated, thriving cell.

Where do we get our probiotics from?

  • All the lactobacillus from our mother when we pass through the birth canal as well as through the amnionic fluid, through core blood and from breast milk.
  • Those species are not in the environment so humans are not designed to consume those species.
  • Spores on the other hand are found all over in the environment
Megasporebiotic
  • Was developed by Dr. Simon Cutting, Ph.D
  • The only dietary supplement probiotic that contains Bacillus Clausii – a strain tested for over 50 years.
  • Contains 5 efficacious bacillus spore probiotics in the consortium – each strain is backed up by a history of use and by published science.
  • Delivers over 4 billion live probiotic cells daily – a dose that matches and exceeds all prescription products of the same strains. The single most powerful spore probiotic formulation.
  • Blended with a pre-biotic to enhance colonization.

Microbiota Balance

  • Spores produce a significant number of potent antibiotics that control bacterial over-growth in the GI tract
  • Spores conduct competitive exclusion of pathogenic organisms to help maintain microbiota balance. They fight for space and nutrients to eliminate the invading species. Such as candida or c diff.
  • Spores have the ability to increase the numbers of the important GI tract commensals, such as lactobacillus.

Immunemodulation  means a down regulation when it’s over active or up regulation when it is under active.

Digestive Aid

  • Bacillus probiotics has been shown to produce key enzymes that help the digestion of food products and alleviate bloating, cramping and discomfort. Enzymes like alpha-amylase, lactase, protease and lipase are improved with the use of Bacillus.
  • Dysbiosis (i.e. the presence of harmful bacteria and the imbalance of good bacteria in the GI tract) is the main cause of digestive disorders and can be argued as being the root cause of most disease. Dysbiosis is also responsible for incomplete digestion of consumed foods. Studies have shown that Bacillus probiotics help prevent the growth of harmful bacteria and promotes the growth of beneficial bacteria – thus alleviating dysbiosis.

Key Nutrient Production

  • Production of vitamins – Bacillus probiotics have been shown to produce important amounts of vitamin K and biotin in the large intestines. Absorption of these vitamins are high as they are produced at the sight of absorption.
  • Bacillus also digests resistant starches and non-starch polysaccharides (is a major component of dietary fiber) to short-chain fatty acids, mainly acetate, propionate, and butyrate, which stimulates colonic blood flow and fluid and electrolyte uptake
  • New Bacillus Indicus HU36 – produces high levels of carotenoids that are of the highest bioavailability.

Why these 5 strains?                                    Ingredients_Megaspore

Bacillus Subtilis HU58

  • Widely used, safe and highly effective
  • Produces over 12 affective antibiotics
  • Makes nattokinase and vitamin K2
  • Highly important for immune development and stimulation of the immune system

Bacillus Indicus HU36

  • Potent immune stimulation
  • Produces high levels of carotenoids – lycopene, axtaxanthin, beta-caroten, lutin.
  • Produces quinols and vitamins
  • The most effective antioxidants on the market.

Bacillus Clausii

  • Most widely used probiotic drug in the world.
  • Potent immune stimulator
  • Antibiotic resistant for use during antibiotic treatment

Bacillus Licheniformis

  • Produces antibiotic bacitracin.
  • Produces protease for digestion and helps protein digestion.
  • Produces whole spectrum of B vitamins and Folic acid.

Bacillus Coangulans

  • Very well studied and long history of use
  • Very effective against IBS, Crohn’s.
  • Produces L+ optical from of lactic acid
  • Potent immune stimulation

Dose, unlike lactobacillus sp and bifidobacterium sp, bacillus spores are found in concentrations around 2 million cells in the gut.

With a dose of just over 4 billion live cells daily, megaspore offers a potent probiotic effect as the dose exceeds the endogenous species by 2000 times / highest on the market.

MegaSpore is both transient and a colonizer.

It is both, which is another unique aspect of these strains.

It is transient because it has about a 21-27 day life cycle in the digestive system. Each individual cell spends about that much time in the gut in various sections and tissues. During their time in the gut, they do attach and colonize.

They attach, they metabolize, they grow by binary fission and they alter the environment around themselves.

If you took just a single dose of Megaspore once, you will find those strains in your gut and stool samples for 21+ days. The digestive system is something like 30 ft long from end to end and it has the surface area of a professional tennis court, so this is a lot of ground to cover.

The strains have the unique ability to exist in various segments of the digestive tract and in various tissues; the mucosa and epithelium.

So when you consume a capsule, the cells move along through your digestive tract and colonize different locations. Some stay in the upper GI (small bowel), some go on to ascending colon, some to the transverse colon, some to the distal.

They attach there and start multiplying to build up their number.

But with that one does, they get fairly spread out, so additional doses are good as you do 2 things:

  1. You increase their numbers so they can cover more tissue and
  2. You get that continuous immune stimulation/modulation from the daily exposure to them. Especially in the Peyer’s patches. Peyer’s patches are organized lymphoid nodules usually found in the lowest portion of the small intestine and the ileum. They are important in immune surveillance and generate immune response within the mucosa.

Why do the bacteria leave the GI tract? They are programmed to leave the gut at some interval because it is crucial to their survival and spread. They use the environment to transfer from host to host. So they have to leave and enter back into the environment to find the next host. This is how they have spread all over the globe.

So they have it programmed in their DNA to re-sporulate and leave the body at some point. But they do leave behind some of their new cells, which will also leave about 21 days after they were created.

Nature has designed them to be consumed continuously as our ancestors did. That daily stimulation/modulation of our immune tissue by the spores is critical to immune function. Also keeping their numbers up in the gut is a big benefit to us.

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Weight Gain – Weight loss – Gut Bacteria

Obesity can cause major health issues such as diabetes and

cardiovascular disease.

 

Now, the question is how much do lifestyle, diet and the microbiome (gut bacteria) play a role in this?

Scientists have found that gut bacteria play a key role in digestion and fat absorption, even in the amount of calories one absorbs from food. That is why some people can eat whatever they want and how much they want and never really gain weight while others eat a restricted diet and still gain weight.

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Two groups of gut bacteria

Bacteroidetes and
Firmicutes

have been studied in mice in regard to obesity.

Scientists took two groups of sterile mice, meaning they killed all bacteria in the mice’s gut prior to the experiment, and reintroduced firmicutes and bacteroidetes in different ratios.

The mice with a greater amount of firmicutes gained weight and actually ended up being obese in comparison to the other mice with less firmicutes, while both groups ate the same food.

What happens is that firmicutes are able to extract more calories from food in the form of fatty acids.

Also, the kind of food you eat will cause a shift in the microbiota. Eating meals high in bad fats, such as vegetable oils, and high calories, leads to the die off of gram negative bacteria and specifically a die off of bacteroidetes.

Bacteroidetes are the kind you want more of in the gut in comparison to the firmicutes if you want to stay lean.

A high fat and a high caloric diet causes the die off of gram-negative bacteria.   When they die, they release Lipopolysaccharides (LPS) from the outer layer of the cell.

The German physician and bacteriologist Richard Pfeiffer (1858 – 1945) discovered those LPS’s and coined the term “endotoxin”.

Endotoxins are kept in the bacterial cell and only released when the cell wall is destroyed.

Now, those endotoxins cause gut inflammation and the loosening of the tight junction which hold the cells of the gut lining together. Leaky gut causes long term inflammatory responses which changes the microbiome and the person ends up with the formation of an obese gut flora.

The obese microbiome determines your cravings, how much you eat, and extracts more calories out of the food you eat.

Lifestyle change by itself is simply not enough to overcome weight gain and inflammation.

Exercise for example counts only about 20 % toward weight loss while

Diet counts about 80 %.

There Is HOPE

for someone who is overweight and has trouble losing weight.

Dietary changes toward a healthy diet with healthy fats, fiber rich foods, and less calories can change the microbiom within 24 hours.

References

(1) Overweight and obese adults (self-reported), 2011, Statistics Canada, http://www.statcan.gc.ca/pub/82-625-x/2012001/article/11664-eng.htm (October 29, 2012)

(2) Ley, R.E., Turnbaugh, P.J., Klein, S., and Gordon, J.I. (2006). Microbial ecology: human gut microbes associated with obesity. Nature 444, 1022– 1023.

(3) Semova, I., Carten, J.D., Stombaugh, J., Mackey, L.C., Knight, R., Farber, S.A., and Rawls, J.F. (2012). Microbiota Regulate Intestinal Absorption and Metabolism of Fatty Acids in the Zebrafish. Cell Host Microbe 12, 277-288.

(4) Backhed, F., Ding, H., Wang, T., Hooper, L.V., Koh, G.Y., Nagy, A., Semenkovich, C.F., and Gordon, J.I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proc. Natl. Acad. Sci. USA 101, 15718–15723.

Probiotics – the Truth and the Misconception of Re-Seeding the Gut

 Probiotics being used to Re-Seed the Gut  

The hypothesis of the probiotic industry is that we can re-seed the gut with the good bacteria. They use the same model as we would re-seed a bare spot in our lawn. You take a few grass seeds, sprinkle it on the dirt, water, fertilize and it grows back to a full lush lawn.

Taking probiotics orally with factory grown strains of bacteria to re-seed the gut is simply

NOT

 possible

You probably heard about the Human Microbiome Project, which taught us a lot about the microbiota which we didn’t know before.

What do we know about Probiotics?

  • We know that they keep the bad bacteria in check
  • We know that we receive ALL of the lactobacillus and bifidobacterium species that we currently have in our gut, from our mother. They are called commensal bacteria.
  • We know that we receive those bacteria during child birth by passing through the vagina, through mother’s milk, through skin to skin contact with our mother, father and other family member.
  • We know that after 838 days after birth, we have our own, unique set of gut microbes, which is basically our adult microbiota.
  • We know that food influences the gut microbiota for the better or worse.
  • We know that our lifestyle influences the microbiome. Stress would be a negative influence, while relaxation would be a positive.
  • We know that antibiotics kill all kinds of strains in the gut, the good and the bad.

How did our Ancestors get their Probiotics?                                                  

  • Our ancestors lived from the land as hunters and gatherers
  • They searched for roots. They had to dig up the dirt to get to them and were exposed to lots and lots of bacteria and spores that lived in the dirt.
  • They did not go home and scrub their hands and cleaned their fingernails to get rid of bacteria
  • They did not use anti-bacterial soap or gels
  • They ate the animals they hunted which ate the natural grass
  • So our ancestors were exposed to environmental organisms every day

Bacillus species

Megasporebiotic

You may know that we humans are more bacteria then human.

Let me explain. We have about 10 trillion human cells in our body and 100 trillion bacterial cell.

So Bacterial genes outnumber human genes 150 to 1 (25,000 human genes vs. 3.3 million microbial genes.

One of these species is the Bacillus species.

They live in the human gut and use the environment in spore form as a place to transfer from host to host.

This means they can live in an aerobic, which is the environment, as well as in an anaerobic world, the GI tract.

Bacteria love the GI tract; it is warm, moist, and provides lots of food.

Benefit of a healthy microbiome in particular the Bacillus Species

  • They train and modulate the immune system by stimulating the lymphoid tissue in the gut. Bacillus species help to improve T and B- cell function and the adaptive immune system and reduce inflammatory processes.
  • They help us digest food. Protease, peptidase, lipase, cellulose, amylase, lipase, lactase and pectinase are probably familiar names to you. You probably have a digestive enzyme supplement at home that includes all or some of those.  Guess what, Bacillus species produce those digestive enzymes I listed above. They also digest starches and non-starch polysaccharides (cellulose from plants such as broccoli) without producing any gas.
  • They help balance the microbiota. Bacillus species keep harmful bacteria in check and they produce nutrients that are designed specifically to feed the healthy microbes. In other words, they create a healthy environment in our gut where the good guys can flourish and do their job while the bad guys are being eliminated and held in check.
  • They produce nutrients in the gut. B vitamins are produced by bacillus species. As you know those are important for the nervous system as well as key methylation functions. Vitamin K2 is also produced by gut bacteria which is important for heart and artery health but mostly used by the bacteria themselves.
  • They produce short-chain fatty acids (SCFAs) which are very important to keep the gut healthy. They dampen inflammation and prevent leaky gut.

Megaspore is the first probiotic that includes 5 critical Bacillus species in spore form.

As we just learned Bacillus species live as spores in the environment and come out of the spore form in the GI tract.

The improvement in health, gut function, even behavioral changes of children, elimination of allergies we see in people using Megaspore is remarkable.

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Frequently Asked Questions

What is MegaSporeBiotic?

MegaSporeBiotic is the first, All Spore, pharmaceutical grade probiotic product that takes advantage of nature’s design for a perfect and true probiotic. Physicians Exclusive has identified key spores as both safe and effective at supporting digestive health and boosting immunity.  Physicians Exclusive is making these spores available for the first time in the dietary supplement industry. MegaSporeBiotic is the first dietary supplement probiotic that contains 5 proven pharmaceutical grade bacillus spores including the patented carotenoid rich probiotic strain – B. indicus HU36.

Why is MegaSporeBiotic different from other probiotics sold on the market?

MegaSporeBiotic is the only product with 5 pharmaceutical grade bacillus spore strains. In addition, MegaSporeBiotic is the first probiotic to introduce a strain that produces key nutrients in the digestive system. In this case, the nutrients produced are powerful carotenoid antioxidants. Carotenoids are the beneficial antioxidants found in colored fruits and vegetables. Carotenoids from dietary supplements however are poorly absorbed and most people do not eat as many colored fruits and vegetables as they should, thus supplementation with a carotenoid rich probiotic is highly important. These beneficial bacteria produce high levels of carotenoids right at the sight of absorption, thus allowing for optimum uptake into the body. MegaSporeBiotic is the first and only probiotic with such a feature.

What is a Probiotic?

Probiotics are the fastest growing category in the supplement industry.  Recent research done by the NIH has defined probiotics by a strict criteria:

  1. The organism must be a normally occurring organism in the digestive tract.
  2. In order to consistently trigger a healthy boost in immune function the organism must be supplemented in concentrations higher than what normally occurs in the digestive tract.
  3. The organism must be able to survive in the digestive tract as well as in the environment.

Interestingly enough there are almost no probiotics in the marketplace that meet all three of these criteria!

Why doesn’t MegaSporeBiotic contain lactobacillus or bifidobacter species of probiotics?

Lactobacillus and Bifidobacter species do meet the first requirement according to the new probiotic criteria defined by research from the Human Microbiome Project that is run by the National Institutes for Health.  That is they do naturally occur in the digestive tract.  In fact lactobacillus and bifidobacter species are in very high concentrations in the digestive tract of humans.   This is exactly why these 2 bacteria cannot meet criteria two.  There are in excess of 20 trillion lactobacillus and bifidobacter species in the average human digestive tract.  Supplements today contain100 billion strains on the high end.  This is nowhere near the amount that would be necessary to stimulate the immune system.  This also assumes that the bacteria will survive the digestive tract.  Research shows that a majority of  orally supplemented lactobacillus and bifidobacter species  are destroyed by the conditions found in the stomach and upper digestive tract.  Lastly, most lactobacillus and bifidobacter species are anaerobic organisms that are designed to live in the digestive tract.  They don’t normally live in the environment because they are sensitive to the presence of oxygen, UV light and other chemicals found in the natural environment. This means they do not fit criteria 3 of our new definition of probiotics. Its important to note that an individual gets their initial dose of lactobacillus and bifidobacter species from their mother through birth and breast feeding. Later in life, orally derived probiotics must be organisms that live naturally in the environment as well at the digestive system so that exposure to these organisms are possible.

Why should I switch to MegaSporeBiotic?

MegaSporeBiotic offers functions that other common probiotics do not.  Effective probiotics go beyond digestive health. Effective probiotics are critical for immune function, immune stimulation, managing populations of dangerous bacteria, digestion of cholesterol, neutralizing toxins, production of key nutrients, etc. Unless your current probiotic contains high doses of several spore strains, it is not providing all these beneficial affects. Use MegaSporeBiotic to take complete advantage of all the functions of a true probiotic.

What kind of spores are present in MegaSporeBiotic?

MegaSporeBiotic contains 5 pharmaceutical grade strains that each have unique function and thus contribute to the overall effectiveness of the product. Below is a brief description of each:

1) Bacillus Indicus HU36 – The first carotenoid rich probiotic strain offered to the dietary supplement market. An isolate from humans, Indicus HU36 produces high levels of powerful carotenoids (antioxidants) at the site of absorption. Carotenoids do not survive the gastric system well. HU36 however, has demonstrated the ability to survive past the stomach acid and produce the carotenoids at their site of absorption in the gut.  This makes the carotenoids produced by HU 36 the most bioavailable supplementary carotenoids in the marketplace. HU36 gives MegaSporeBiotic a function that no other probiotic formulations on the market can claim-it provides key nutrients in their most potent form.

2) Bacillus Clausii – This strain is the largest selling strain of prescription probiotic in the world. For the first time, this strain is made available to the U.S. dietary supplement industry and is available exclusively to healthcare professionals. Bacillus Clausii is recommended for use during antibiotic treatment due to its ability to resist damage from a variety of common antibiotics. MegaSporeBiotic has the unique function of being a powerful supplement that can be used in adjunct with antibiotic therapy to keep the organisms balanced in the gut.

3) Bacillus Subtilis HU58 – Bacillus Subtilis has been extensively studied on a genetic and functional level. There are several probiotic products in the pharmaceutical and agricultural markets that utilize this powerful probiotic. One very interesting function of Bacillus Subtilis is its ability to produce nearly 12 strong antibiotics that are potent fighters of opportunistic and harmful bacteria. Bacillus Subtilis HU58 offers MegaSporeBiotic the ability to prevent harmful bacteria growth in a variety of conditions. In addition, HU58 produces a very healthy compound called Nattokinase. Nattokinase is secreted from vegetative cells of Bacillus subtilis and has been shown to reduce blood pressure, reduce cholesterol and reduce excessive clotting by fibrinolysis. Along with Nattokinase, Bacillus subtilis also produces a number of other nutrients that have systemic health benefits such as B vitamins and Vitamin K2. Bacillus subtilis HU58 offers MegaSporeBiotic the important function of fighting off pathogenic bacteria and producing key nutrients in the gut itself. In addition, HU58 is an extremely potent immune stimulator. It has the function of germinating in the small intestines to some degree and this offers the effect of broad-spectrum immune stimulation.

4) Bacillus Licheniformis – A probiotic often found with Bacillus subtilis and other bacillus species, licheniformis has been shown to have a potent effect of preventing the growth of harmful bacteria via the production of a common antibiotic called bacitracin. It is also a potent immune stimulator. Another very important feature of bacillus licheniformis is its ability to produce highly effective and stable protease enzymes in the gut that assist in the digestion and absorption of proteins. Lastly, licheniformis also produces the whole spectrum of B vitamins in the gut including folic acid and biotin and acts as an important nutrient factory in the digestive system.

5) Bacillus Coagulans – A very well studied probiotic in the spore family that has a profound effect on inflammatory conditions such as IBS and Crohn’s. Bacillus coagulans offers MegaSporebiotic an expanded effect of controlling these common inflammatory bowel conditions in addition to its potent immune boosting activity. Coagulans has the unique attribute of producing lactic acid and specifically the L+ optical isomer of lactic acid, which has been shown to have a more profound effect on immune stimulation and gut defense than the other forms of lactic acid produced by conventional probiotics. Coagulans is also a tremendous colonizer and thus assures proper colonization of MEGAsporebiotic, which in turn will produce the beneficial effects required. Coagulans also plays a key role in digestion of food and absorption of nutrients. In fact, Coagulans can digest incoming fat to reduce the uptake of cholesterol. Coagulans adds another dimension to MEGAsporebiotic, giving it a potent ability to fight inflammatory conditions, aid in digestion and prevent the growth of harmful bacteria.

What is the Shelf-Life of MegaSporeBiotic?

2 Years, expiration date will be indicated on the box.

What are the side effects of taking MegaSporeBiotic?

None have been reported for MegaSporeBiotic.

Where can I purchase MegaSporeBiotic?

Through your health care professional. Purchase here

Why should I take MegaSporeBiotic with a meal?

The amino acids and carbohydrates in food help the spores move from their dormant (spore state) to their active (vegetative state) form in the GI. There are tremendous immune benefits if the spores are made to germinate into their vegetative state in the upper GI itself and so taking just after a meal (10-20 mins after) is ideal.

If a probiotic has no spot to colonize, can it cause problems until it is expelled? 

In theory, yes. The bacteria could be seen as an invading species and the body can mount an immune response to it. The response would be a pro-inflammatory innate response which can then harm other tissues in the area as well. It’s important to know that a supplemented probiotic has a place in the individuals microbiota – with bacillus spores being such universal probiotics, you can feel comfortable that they have a spot to colonize every time.

How do you know what to give clients and for what conditons? 

Health in general starts in the gut. Hippocrates said it in 400 B.C. and since then modern science has proven it. Any immune dysfunction (auto-immune, allergies, food sensitivities, rashes, psoriasis, eczema, rheumatoid arthritis, gout, etc.) can be traced back to a dysfunction in the GI. Any inflammatory condition can as well. Now, modern science has shown us that weight control, mood, depression and other mental disorders are also connected to the gut (the second brain). Even chronic diseases such as diabetes, heart disease, cancer, etc. can be traced back to the gut. Everything starts in the GI. With that in mind, all your clients should be on a daily dose of this probiotic as well as a diet that supports a healthy flora. It’s as essential as any multivitamin, greens drink or fish oil product that people may use as part of their daily nutrition. So start all clients on it and nearly everyone (despite their condition or ailment), will see some benefit as you are now replacing an essential nutrient that has been missing from their diet. For clients that present with a strong yeast issue or those with strong inflammatory conditions (Crohn’s, IBD, Ulcerative colitis, etc.) should titrate the dose up slowly. Starting with 1 or 1/2  cap every other day for a week or until they can tolerate, then 1 cap per day using the same discretion and finally 2 caps per day.  Symptoms to watch out for include intestinal cramping and diarrhea. Those symptoms can be avoided, reduced or eliminated by titrating up very slowly.

Can live fermented foods colonize the gut effectively? And would these spore probiotics help the SIBO condition, which has been characterized as an overgrowth of good bacteria. Also can candida excess yeast be helped?  

Fermented foods are great for the GI, but the benefits don’t typically come from the microorganisms in the food going in and colonizing, it comes from the ferment itself. The many nutrients the bacteria made while fermenting the foods are what helps the GI and the immune system from fermented foods. The problem however is they don’t do much to alter the Dysbiosis one may have in the GI. This is where a true and effective probiotic comes in. MegaSporeBiotic contains one of the only strains that have been shown in studies to actually alter the GI flora when it colonizes. This is a difficult task when you consider that the flora is made up of nearly 100 trillion cells and the probiotic is there in a concentration of just a few billion. But some strains are specialized to do this type of work and our strain bacillus Subtilis HU58 is one such strain.

Another key strain in the formula (bacillus clausii), has been used as a prescription treatment for SIBO for a number of years. It can be very effective in your patients suffering with SIBO.

We have had numerous cases of candidiasis that have seen great benefit from this product. There can be some strange looking excrement for a period of time as the yeast leaves the system, but we have always seen very consistent and positive results.

 

In the case of dysbiosis would there be a need to reduce the population of the good guys and bad guys before repopulating the GIT?

Yes, you can certainly have too many of certain good guys. In fact, a commensal bacterium in your GI is a “good guy” only until a certain point. Once that “good guy” reaches a certain population level, it can easily become a “bad guy” as in being a problem for the system. This is the issue in SIBO. One of the most profound effects of these bacillus spores in MegaSporeBiotic is their ability to “police” the GI. They facilitate and support the growth of the “good guys” that are under population and can reduce the numbers of the bacterium that are over-grown. They create a modulating effect on the microbiota. Start with MegaSporeBiotic, let these strains regulate the microbiota, then use foods and supplements that support the growth of the good bacteria. Taking the spores daily will ensure that the balance is not lost again.

How is your product different from Lactobacillus sporogenes by Thorne? 

Lactobacillus Sporongenes is a mislabeling of Bacillus Coagulans. We will refer to the product under its correct name which is bacillus coagulans. Bacillus coagulans is a spore former with the benefits we talked about with our product, in fact, we also have bacillus coagulans in our formulation as one of the 5 strains. There are however some very important differences between MegaSporeBiotic and the Bacillus Coagulans product from Throne, they are as follows:

1)      We are verified to be in 100% spore form – this is critical as spore formers are also unable to survive the journey to the intestines unless they are in spore form. From what we have seen, other products that may contain 1 or 2 spores have only some of those strains in spore form; the rest is in vegetative cell form. This makes them less effective.

2)      We have 5 critical strains that work in synergy. These bacillus spores aren’t found by themselves in nature. In nature these spores are typically in co-existence with other bacillus spores and they support one another in the human body. Having an effective consortium of the right spores is more how nature intended. In addition, these various spores perform different functions in the body. Having just 1 of the strains means at least 1/5 less function.

3)      With 5 strains you get a whole spectrum of nutrient production that you won’t see with just 1 strain. Between the 5 they produce the whole spectrum of B vitamins, quinols, vitamin K2, digestive enzymes, etc.  Each of the strains produces a different set of micronutrients.

4)      Lastly, ours contains the patented bacillus indicus HU36 – this is the world’s first carotenoid (antioxidant) rich probiotic. This strain colonizes in the GI and produces RDA levels of carotenoids right at the site of absorption.

Can probiotics or spore probiotics be safely taken when breast feeding or during pregnancy?

Yes, we have a number of clients and individuals who are taking the product during pregnancy and nursing. If the pregnant or nursing mother has strong inflammatory conditions or yeast issues, they should also be titrated up so there isn’t a detox reaction.

When using MegaSporeBiotic, is dosing once per day or more often depending upon clinical presentation of  the client? 

The product should always be dosed once per day only. There is no need or benefit in splitting the dose to 2 or more per day or doubling the dose of 2 capsules. You want to get the full dose of probiotics in at once. This again is best about 10-20 minutes after a meal.

Would like to know your view on VSL #3 and S. boulardii and the use of Lactoferrin

VSL 3 is a probiotic formulation that uses the same rationale as 95% of probiotics out in the market place. It uses 8-10 strains of various lactobacillus and bifidobacterium species but has focused on formulating the largest numbers of these strains – in one of their formulations they claim nearly 900 Billion CFU. In our opinion, it is an enhanced version of many probiotics found in the market today. It may have some effect on acute symptoms, but we would not feel comfortable saying that it performs as a “probiotic” per the World Health Organization definition.

Saccharomyces boulardii is a strain we like and we believe is effective. In fact, we have used it ourselves. It fits natures design as a probiotic and the scientific definition as well. It is however a probiotic fungus and not a bacteria. Although it can be effective against diarrhea, it has limited function. To use it by itself as a daily probiotic is incomplete therapy. We use MegaSporeBiotic and supplement from time to time with S. boulardii in cases of severe and acute diarrhea.

Lactoferrin is an immune component that can be useful for acute infections or conditions. It’s not designed to be used chronically. If you look in nature, the highest concentration of lactoferrin is found in human colostrum, then the concentration reduces in human milk. Colostrum only comes in the first few days after birth and then milk comes in where nature has designed for the lactoferrin concentration to reduce. Of course the milk eventually stops as well and so humans have not evolved to require or use lactoferrin their entire life. Its important to establish the innate immune system in newborns and to protect the newborn from infection as newborns are not producing their own immune cells and then it becomes less important as the newborn matures and starts to produce its own innate immunity components. The strains in MegaSporeBiotic are a potent immune modulator and they do this equally for children and adults. In fact, it has been shown that our immune systems are likely designed with a need for this daily stimulation and modulation by bacillus spores. This would not be surprising from an evolutionary stand point when you consider that our ancestors got a daily dose of these strains their entire lives.

What is the general length of time needed to get the gut to self-inoculate? I.e. how long do you have to take these spores before you can ease up and survive on your own?

Nature has designed these spores to be a daily, foundational food. They are transient microorganisms, thus they don’t stay in the GI forever. They go in, perform a function and leave. This is important as this helps keep their numbers in the GI relatively low which means each dose has an effect. It takes them about 21 days to reach a steady state concentration in the GI with daily supplementing and at this stage is where they are the most effective in regulating the GI. At this time, it’s important to consume a diet low in refined sugars and higher in fibers to facilitate the growth of the individual’s own good bacteria. In fact, the spores can also increase the growth of the good bacteria. Between the spores being present and the improved diet, the individual will go into a state where they have the right microbiota balance. If the spores are removed, then you are tipping the balance back towards Dysbiosis. The use of the spores on a daily basis is a very important maintenance practice. We are bombarding our GI on a daily basis with things that shift the balance to Dysbiosis and so the spores are required to remain and police our GI.

What are the actual number results from GI studies of all the carotenoids and vitmain K2 etc.?

In the GI study we focused on the caroteniods in terms of being able to enumerate the quantities produced and absorbed. We did not focus on the vitamins and enzymes. The study showed that on average, after 3-4 weeks of daily use, the strain was producing roughly 800ug of carotenoids per day. These carotenoids are produced right at the site of absorption and are thus roughly 10 times more bioavailable than standard, supplemented carotenoids. The researchers concluded that it reaches the Recommended Daily Allowance of carotenoids.

Any healing crisis that may develop when you first start Megasporebiotic and they start killing off yeasts or other pathogens? 

As with any product that is effective in restoring balance to an unhealthy intestinal tract the chance for your clients to experience herxheimer reactions is possible.  Because of this we recommend that the dose be titrated up slowly to control detox reactions.  The most frequent symptoms reported are intestinal cramping and loose stools.  Decreasing dose eliminates any uncomfortable symptoms.

What conditions are specific for MegaSporeBiotic?

Clinically, we have benefited the following conditions and other doctors have reported major benefits in these listed conditions as well:

  • Crohn’S, IBS, IBD and colitis
  • Minor and major gastro discomfort – gas, bloating, indigestion
  • Acid reflux/GERD
  • Hashimoto’s disease
  • Cystic acne
  • Rheumatoid arthritis
  • Allergies, asthma, eczema, psoriasis.

Can pets (cats & dogs) be supplemented with MegaSporeBiotic? 

Yes, the strains are universal probiotics and are used in all types of animals and livestock throughout the world, including marine life. Take one capsule, pull it apart and sprinkle it on their food.

Will the spore still work if you pull the capsule apart and you add it to water or food? 

Absolutely. This is the preferred way to administer to children. It can be pulled apart and the powder mixed into nearly any food or drink. It is temperature stable, so it can even be mixed into hot tea, coffee or soup. There is no real taste impact of the powder.

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Doreen, NC
This has been a year of learning experiences. I have gone to several doctors over the years. And each time I have come away frustrated with all of them. They don’t listen or they hear what they want. I have listened to their advice and stuck with it for years. I was on BP meds, two diabetic medications, and Cholesterol meds. when I met Linda. Linda told me things no one had ever mentioned before. She told me that from the test results I gave her that I was probably sensitive to Gluten and had leaky gut issues. She worked up a protocol and supplements for me. I changed my diet with Linda’s help and the results were incredible. I have lost over 50 pounds but, more important than that is I feel so much better. My children have only known me as a large (size 20-22) person. They are getting used to the new and happier (size 10) person I am now. I am off both diabetic meds and cholesterol meds. My BP meds have been lowered. Linda is very caring, listens to you and answers all your questions. She is diligent when giving you advise. She is a wealth if information. My suggestion for everyone is to listen to Linda’s suggestions and advise, and as the saying goes “Just do it.” Thank you so much Linda.
Rich, CA
I was suffering from chronic cystic acne around my chin before working with Linda. I would try and keep a food journal to try and figure out what I was eating that was causing this debilitating condition. The problem is that food sensitivities can show up 72 hours later, and it was too hard to figure out which food item it was. I finally decided to just work with Linda and take the MRT test. I had enough of guessing what foods were causing the cystic acne. When I got the results back, I was surprised about the items I tested sensitive to. I simply removed all those items from my diet, and my face got to its clearest in years within three weeks! No more painful nodules on my face! I’ve noticed that if I eat items from my list, I can feel a reaction on my face coming, so I know the test is accurate. I just stop eating those items, and my face clears again. I highly recommend working with Linda. She is very attentive to detail, and is committed to you having the best results for your condition related to diet. I only wish I did this earlier.


Elfriede, Germany
I’m so happy to report that the inflammation in my knee is gone and I am able to walk without a cane. Linda recommended to get off gluten and gave me the right kind of supplements. I am 88 years old and not being dependent on a cane is the best thing that happened to me in a long time. I have more energy, can think better, can clean my apartment and cook my own meals.

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Contact the Owner of Exclusively Holistic:
Linda Wilbert – Stewart, FDN-Practitioner, HHP, HC

 

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