MegaSpore & Recurrent C Diff Study

A Spore‐Forming Probiotic Supplement Improves the Intestinal Immune Response and Protects the Intestinal Health During Recurrent Clostridioides difficile Colonization in Mice

The full text of the study can be found here

The Problem with C. diff

Clostridioides difficile, formerly known as Clostridium difficile and commonly referred to as C. diff, is a pathogenic bacteria that can infiltrate the human gut, causing

severe diarrhea,

stomach pain,

fever, and

loss of appetite.¹ 

C. diff is an opportunistic pathogen, meaning that it can take over the gut when other healthy commensal gut bacteria are depleted.¹ For this reason, C. diff infection is common after patients take broad-spectrum antibiotics. While antibiotics can kill off other infectious microbes, they also take a toll on our healthy gut bacteria, causing dysbiosis and impairing gut immune function. This creates the perfect storm for C. diff infection, particularly among the elderly populations. In fact, C. diff is the leading cause of hospital-acquired infections since antibiotic therapies and compromised immune function are so prevalent in these settings.²

Recurrent C. diff Infection is a huge risk for hospital patients

C. diff is often treated with antibiotics, leading to a vicious, downward spiral of recurrent C. diff infections. Researchers speculate that improving the gut microbiome with probiotics can improve health outcomes in the most vulnerable populations. Indeed, probiotic therapies are rapidly gaining popularity as a standard protocol for those suffering from C. diff and other hospital-acquired infections.³

Can probiotics improve health outcomes in C. diff sufferers? 

Among the numerous probiotics, Bacillus spore-based probiotics stand out as an attractive treatment option. These are highly resilient probiotics that are capable of withstanding

low stomach acid,

extreme temperatures, and

long shelf-lives,

meaning that they arrive in the colon fully intact.

In this study, researchers at Cleveland Clinic used the probiotic MegaSporeBiotic, which is a unique blend of Bacillus species, including B. licheniformis SL-307, B. indicus HU36, B. subtilis HU58, B. clausii SC-109, and B. coagulans SC-208According to current research, these strains are shown to compete with C. diff for vital nutrients such as iron, neutralize C. diff toxins, and boost gut immune function.⁴⁻⁶

C. diff Study Summary:

Using a murine model, researchers at Cleveland Clinic investigated the impact of MegaSporeBiotic on GI health in C. diff sufferers. Female mice were inoculated with C. diff and then randomly assigned to receive either saline or MegaSporeBiotic.⁷ Mice were then treated with the antibiotic vancomycin for 10 days and re-inoculated with C. diff at day 5 of antibiotic treatment.⁷ After antibiotic treatment was complete, blood samples and intestinal contents were collected for analysis. Results indicated that MegaSporeBiotic supplementation reversed the unwanted changes in cecum weight induced by the antibiotics and balanced the immune response within the gut. A stark reduction in cecum weight following antibiotics has been associated with the broad-spectrum depletion of the microbiome. Reversing this reduction indicates that supplementation with MegaSporeBiotic can help to repopulate the gut microbiome following antibiotic-induced decimation. Furthermore, MegaSporeBiotic supplementation competitively excludes C. diff by utilizing available iron, reduces the expression of inflammatory biomarkers like TNF-α and calprotectin, and increases the expression of tight junction proteins necessary for healthy gut barrier function. This groundbreaking research highlights the role of these unique spore strains in reconditioning the gut microbiome, improving intestinal immunity, and reducing gut inflammation following C. diff infections and broad-spectrum antibiotic use.⁷ 

These results demonstrate that the unique spore strains in MegaSporeBiotic have a powerful protective effect in the fight to control recurrent infections from pathogenic spores like C. diff. These findings validate a great deal of what we already knew about our unique Bacillus spore-based probiotic strains and provide us with even more insights that we hope to investigate further in human clinical trials.

MegaSporeBiotic
Info on MegaSpore & where to purchase it
References
1. Theriot CM, Young VB.Interactions between the gastrointestinal microbiome and Clostridium difficile. Annu Rev Microbiol. 2015;69:445-461.

2. McFarland LV. Antibiotic-associated diarrhea: epidemiology, trends and treatment. Future Microbiol. 2008;3(5):563-578.

3. Theriot CM, Young VB.Interactions between the gastrointestinal microbiome and Clostridium difficile. Annu Rev Microbiol. 2015;69:445-461.

4. Jin K, et al. Clostridium difficile infections in China. J Biomed Res. 2010;24(6):411-416.

5. Ripert G, et al. Secreted compounds of the probiotic Bacillus clausii strain O/C inhibit the cytotoxic effects induced by Clostridium difficile and Bacillus cereus toxins. Antimicrob Agents Chemother. 2016;60(6):3445-3454.

6. Ho TD, Ellermeier CD. Ferric uptake regulator Fur control of putative iron acquisition systems in Clostridium difficile. DiRita VJ, ed. J Bacteriol. 2015;197(18):2930-2940.

7. Kapourchali FR, et al. A Spore‐Forming Probiotic Supplement Improves the Intestinal Immune Response and Protects the Intestinal Health During Recurrent Clostridioides difficile Colonization in Mice. Journal of Parenteral and Enteral Nutrition. 2020; 00(0): 1–11.

Study on Blood Ammonia Level Using Probiotics

An Oral Formulation of the Probiotic, Bacillus subtilis HU58, Was Safe and Well Tolerated in a Pilot Study of Patients with Hepatic Encephalopathy

Sayed Yossef,1 Frances Clark,1 Sarah S. Bubeck ,2 John Abernethy,3 Thomas Bayne, 4Kiran Krishnan,4 and Aicacia Young4

Published 30 June 2020 in the journal of Evidence-Based Complementary and Alternative Medicine

Hepatic Encephalopathy

HE for short is the inability of the liver to process ammonia and is associated with loss of brain function because of high ammonia levels. Ammonia is a byproduct of protein fermentation in the gut and is a neurotoxin. Detoxification of ammonia happens in the liver during protein metabolism. In people with acute or chronic liver diseases, the liver has trouble detoxifying the amount of ammonia that comes from the gut. Consequently, the ammonia concentration in the blood rises and causes dysfunctional neurotransmission and brain swelling when it interacts with the nervous system.

Confusion, Forgetfulness, Mood swings, Changes in sleep patterns and other symptoms of HE are possible.

In this study the probiotic Bacillus subtilis HU58 was used to see if it helps reduce blood ammonia levels in patients with baseline levels >60 mcg/dL.

This is another study that indicates that Bacillus spores can support healthy liver function and detoxification, which can have a direct impact on brain function. 

Patients who participated in this study all took lactulose to manage symptoms and many also took Rifaximin.

Lactulose is used by physicians as standard of care. It promotes the growth of urease-producing gut bacteria. The enzyme urease degrades ammonia and helps to clear this potential toxin from the body by causing loose stool or diarrhea.

As you can see the gut microbiome is involved in the reduction of blood ammonia and Lactulose is utilized for this process. In addition, a healthy and acidic gut aids in the reduction of ammonia absorption into the blood stream.

Researchers speculate that using probiotics, such as B. subtilits HU58, may enhance the ammonia-clearing capacity of the gut by improving microbial diversity and reducing intestinal pH.

Study Summary  (read the study here)  

To test this theory, researchers recruited 35 patients with hepatic encephalophathy to participate in a double-blind, placebo-controlled trial. The study group received lactulose + B. subtilis HU58 daily for 4 weeks, while the control group received only lactulose. At the end of the trial, researchers discovered that those with the highest baseline levels of ammonia saw the most significant improvements while using probiotics with lactulose.

When stratifying the patients by baseline blood ammonia levels, researchers found that the patients taking B. subtilis HU58 that entered the trial with higher baseline levels (>60 mcg/dL) saw the most significant improvement in blood ammonia levels.

Furthermore, the probiotic group had a reduction in adverse events, demonstrating that B. subtilis HU58 was well-tolerated among HE patients.

This study shows that B. subtilis HU58 used alongside lactulose is safe and effective in reducing blood ammonia in people with hepatic encephalopathy.

References can be found here

Immune Health

The immune system is your body’s primary mechanism of defense, responsible for protecting you from potentially harmful invaders. It is made up of various cells, tissues, and substances including the skin barrier, red and white blood cells, microbiota, antibodies, and cytokines (cell signaling molecules).

The immune system may be generally broken down into the

innate immune response, your first line of defense, and the

adaptive immune response, which is highly specific against particular intruders.

Immune system dysfunction may result in

allergies

infections

tumors

and autoimmunity.  

Tips how you can protect and support your immune system:

  • healthy lifestyle with the reduction of toxins in cleaning supply, toxins in cosmetics, toxins in water such as Glyphosate
  • a nutritious diet such as the Mediterranean diet and a gluten and/or dairy free diet
  • adequate sleep
  • regular exercise
  • and dietary supplements may help you to support immune health and prevent disease. 

Below is some useful information about top recommended supplements for immune health:

Astragalus (Astragalus membranaceus)
is a botanical herb with antioxidant, anti-inflammatory, immunomodulating, and anticancer properties. While astragalus has traditionally been used in Chinese medicine to treat individuals with increased susceptibility to infections, studies suggest it may improve outcomes of inflammatory conditions and certain cancers.  Research has also shown that astragalus may help stimulate the immune response by increasing white blood cell count.

Probiotics
beneficial microorganisms, may support immune health by modulating innate and adaptive immune responses and inhibiting the growth of pathogens. Probiotic supplements may help to protect healthy individuals against respiratory infections such as the common cold and the flu. Additionally, research has shown that probiotics may be effective in certain immune conditions, including allergies, eczema, human papillomavirus (HPV), and certain drug-resistant infections. This article provides a lot of information about Probiotics and Prebiotics. Prebiotics and probiotics are used to improve the health of the intestinal tract.

Prebiotics

are non-digestible fibers that are used by the gut bacteria. Prebiotics are formulated with fibers such as inulin, fructooligosaccharides (FOS), galactooligosaccharides(GOS) and xylooligosaccharides (XOS). MegaPrebiotic is the only Prebiotic that feeds ONLY the beneficial gut bacteria.

Vitamin C
plays an important role in immune function by supporting both innate and adaptive immune systems. Vitamin C may be obtained from dietary sources such as citrus fruit, papaya, broccoli, and kiwifruit, as well as from dietary supplements. Vitamin C deficiency may result in lowered immunity and a higher risk of infections. Supplementing with vitamin C has been shown to be effective in treating respiratory and systemic infections.

Vitamin D
is a fat-soluble vitamin required in mineral metabolism, bone health, and immune function. Vitamin D deficiency has been associated with an increased risk of autoimmune conditions, including type 1 diabetes, inflammatory bowel disease (IBD), and multiple sclerosis (MS). Research suggests that vitamin D supplementation may reduce the risk of autoimmune conditions, support immune tolerance in autoimmune conditions, and enhance the antimicrobial effect of certain immune cells.  We can get vitamin D from sunshine. Personally I prefer getting it from sunshine instead of supplementation. Please consult your physician to make sure that your calcium levels are not elevated prior to taking vitamin D or increase during vitamin D supplementation.

GERD & Acid Reflux

Millions of people in the United States are suffering from digestive problems which are painful and can be embarrassing.  

  • GERD / Acid reflux
  • Gas / Bloating
  • Stomach cramping or cramping in the intestines
  • Diarrhea / Constipation or both
  • IBS like symptoms
  • H. pylori infection

are the symptoms people struggle with and try to get help from their physician. Complaints about acid reflux or GERD after eating most likely are treated with a prescription of Proton Pump Inhibitors. This kind of medication works by reducing the amount of stomach acid made by glands in the lining of the stomach. Millions of people world wide take this kind of medication.

Stomach pain, Gas, Acid Reflux

The question is: Does your stomach really produce too much stomach acid?

In fact, most people who suffer from acid reflux have too little stomach acid. By taking proton pump inhibitor they reduce the little bit they produce even more.

Let’s think about it, stomach acid starts the digestive process of protein and carbohydrates. With too little gastric juices the chime (pronounced: kime), which is the food that has been mixed with stomach acid, sits in the stomach for a long time, starts to ferment. Gas is being produced by bacteria through the fermentation process, which then has to go somewhere. It creates pressure and discomfort, extends the abdomen, and leaves the stomach through the esophagus and the mouth.

Bottom line is that the pressure from the gas is the problem.

The gas is what pushes the food that sits in the stomach into the esophagus. the burning sensation is caused by the stomach acid that the food is mixed with.

acid reflux, IBS, SIBO, digestive problems,

Let’s take a look at the consequences of low stomach acid.

  • Stomach acid starts the digestive process of protein and carbohydrates  but it also kills bacteria. Bacteria are everywhere and our body is equipped to defend and protect itself. Stomach acid is one way to protect our body from an overload of bacteria but also viruses and parasites. Low stomach acid production therefore increases the chance of having too many bacteria in the stomach and duodenum, the part of the small intestine that connects to the stomach. The immune system now is being taxed with a large amount of pathogens that are not being killed in the stomach before they enter the gut.
  • Stomach acid triggers the production of pancreatic enzymes which help digest carbohydrates and proteins. With too little stomach acid the pancreas will not release adequate amounts of digestive enzymes. As a result the food only partially digests and most likely sits for a long time in the small intestine.
  • But stomach acid also triggers the release of bile into the upper part of the small intestine. Too little bile secretion as a result of a weak trigger by the stomach acid prevents fats from being digested properly. In addition, bile carries the toxins secreted by the liver to the small intestine to be eliminated.
  • Bile also works as a cleaning solution on the gut lining and you can imagine that this mechanism is being reduced with a small amount of bile flowing into the gut.
  • Conjugated bile salts kill the bacteria that produce LPS (Lipo-Poly-Saccharides) which is toxic.
  • In addition the duodenum also produces stomach acid which kills bacteria. Too little acid in this area causes an overgrowth of bacteria where it is not supposed to happen. This causes the fermentation of the food and gas production.
  • Those bacteria in the duodenum produce ammonia and hydrogen gases. Those cause bloating and inflammation on the gut lining.
  • With an overgrowth of fermenting bacteria in the gut, the gut lining becomes inflamed and the mucosal layer compromised. In other words, the gut becomes leaky (leaky gut).
  • When bacteria die they release LPS (Lipo-Poly-Saccharide) which is a toxin. Those neurotoxins can negatively impact the vagal nerve and reduce it’s function. As a result the brain – vegal connection is disturbed and influences the gut peristaltic negatively. In other words, the muscles in the gut lining which move the food through the intestines slow down. Food then sits for a very long time either in the small or the large intestine.
  • H. pylori infection increases and stomach ulcers can develop. While H.pylori is a commensal bacterium, and being held in check by adequate amount of stomach acid it can flourish with too little amount of stomach acid.

As you can see the consequences of low stomach acid are poor carbohydrate and protein digestion of the food you ate, poor bile release, poor fat digestion, bacterial overgrowth, gas production, and the discomfort that comes with it.

SIBO?

When you read this, does it remind you of SIBO like symptoms? SIBO is small intestinal bacterial overgrowth. Stomach acid is the medium that kills bacteria. Bile is the medium that also kills bacteria. Since both, stomach acid and bile, are not produced in adequate amount, the chance of bacterial overgrowth are increasing.

What can you do?

Digestion starts in the brain when we see and smell food. You know that thinking about a lemon will trigger saliva flow in the mouth. By sitting down for a meal without any distraction of the cellphone or tv you can concentrate on the food you are about to eat. Enjoy the colors and the smell (if you eat real food) to trigger the production of saliva and stomach acid.

Saliva excretion increases even more when you start chewing your food. Saliva starts the digestion of carbohydrates but it also triggers the release of stomach acid before you swallow your food.

Stress decreases stomach acid production. Reduce as much stress in your life as possible. Maybe a diary can help you figure out where you can make changes for the better.

Sleep plays a role in stress reduction.

Drinking filtered water during a meal will dilute stomach acid. Try to drink water between meals.

Caffeine consumption can increase cortisol production and therefore can be perceived as a stressor by the body. Caffeine also increases the peristaltic of the large intestine and can cause diarrhea.

Drugs like Aspirin and Tylenol disturb gut function as well as liver function.

Proton Pump Inhibitor drugs reduce stomach acid.

Antibiotic kill the beneficial bacteria as well as the pathogenic and this causes dysbiosis of the microbiome. Taking a spore based probiotic with the antibiotic will eliminate the chance of developing dysbiosis.

Antihistamine reduce stomach acid production

Herbs such as peppermint and ginger increase stomach acid production.

HCL supplement helps increasing stomach acid and brings down the number of H. pylori bacteria count.

Beets help with bile secretion

Bitters help increase stomach acid production and help the release of bile into the small intestine.

Reduce protein consumption until you have adequate stomach acid production.

Digestive enzymes to help with protein digestion and overall digestion of the food you ate.

MegaGuard is the best supplement that helps with low stomach acid production, gastric emptying, and stomach cramps.

Contact me if you need any help or have questions about the subject in this article. Please consult with your physician prior to making decisions about the supplements listed.

MegaSporeBiotic & MegaPreBiotic Study

MegaSporeBiotic & MegaPreBiotic Study
MegaSporeBiotic & MegaPrebiotic Study

Bacillusstrains and a prebiotic fiber blend consistently enhanced metabolic activity

This article is a summary of the study performed on MegaSporeBiotic and MegaPrebiotic.

This study was conducted to assess the effects of the daily use of Megasporebiotic a 5 spore-forming Bacillus strains probiotic in combination with a prebiotic fiber blend MegaPrebiotic on the human gastrointestinal tract.

Prebiotics and probiotics are used to improve the health of the intestinal tract.  Prebiotics are non-digestible fibers that are used by the gut bacteria. Probiotics are considered live micro-organisms.              

Prebiotics are formulated with fibers such as inulin, fructooligosaccharides (FOS), galactooligosaccharides(GOS) and xylooligosaccharides (XOS).

MegaPrebiotic

Probiotic strains that are most often used are Lactobacillus spp., Bifidobacterium spp., Saccharomyces boulardii and Bacillus coagulans.

MegaSporeBiotic

The combination of Prebiotics and Probiotic supplementation has been linked to several health benefits such as improvement of atopic dermatitis(1), reduction of serum lipid profile in patients with type-2 diabetes(2), alleviation of digestive complaints in patients with gastro-intestinal disorders(3) and changes in anthropometric measurements in obese individuals(4).    

In this study Microbiome Labs provided MegaSporebiotic which contains Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans SC-208, Bacillus licheniformis and Bacilllus clausii SC-109 spores and MegaPrebiotic, a blend of prebiotics of fructooligosaccharides from green and gold kiwi furit, xylooligosaccharides from corn cob and ga-lactooligosaccharides from cow milk. 

The daily dosage contained 2 capsules of MegaSporeBiotic and 3775 mg of MegaPrebiotic.    

The test was an in vitro simulation of the human intestinal microbial ecosystem. The setup represented different regions of the human GI tract; the stomach, small intestine and the ascending, the transverse and decending colon.  

Fecal matter was used from three different human adults. Samples for microbial community analysis were collected once a week.

The results showed that the treatment with MegaSporeBiotic and MegaPrebiotic in combination showed a consistently strong increase in butyrate levels for all donors tested.

The results also showed a significant increase in Lactobacillus spp.. This effect was not present when probiotic blend alone was used.

The study showed that these observations stress the fact that the combination of functional fibers (as in MegaPrebiotic) with probiotic strains (as in MegaSpore) could be a useful strategy in modulating the microbial community, as they might selectively stimulate different microbial groups.

Butyrate is used an energy source for the colon lining which provides health promoting properties. Those include anti-inflammatory activity, anti-cancer effects, promotion of satiety and reduction of oxidative stress(5).

FOS from gold kiwi fruit, which is one of the ingredients in MegaPrebiotic increased Faecalibacterium prausnitzii levels significantly in functionally constipated individuals. (6)  Faecalibacterium prausnitzii exerts strong anti-inflammatory activity in the intestinal environment which is mainly linked with the production of butyrate stimulation of regulatory T-cells (7) Furthermore, increased Faecalibacterium prausnitzii levels have been associated with reduction of inflammatory markers (8) and reduction of endotoxemia in obese subjects.

Conclusion:

The combination of Megaspore, which contains five spore-forming Bacillus strains, and a prebiotic MegaPrebiotic, a blend of FOS, GOS and XOS, “consistently affected microbial activity and composition in the human gastrointestinal tract in vitro, with profound effects being observed on colonic butyrate production.

Moreover, when compared with a previous study investigating the impact of the probiotic strains on colonic functionality, the generated data suggest a synergistic effect on the gut microbiome for the synbiotic test product. Given the fact that the probiotic formulation has already been shown to impact metabolic endotoxemia in human individuals, it might be interesting to further investigate the efficacy of the synbiotic formulation in tackling metabolic disorders.”

Reference: 
1 Farid, R., Ahanchian, H Jabbari, F., Moghiman, T. 2011.
Effect of a new symbiotic mixture on atopic dermatitis in children: 
a randomized-controlled trial. Iran. J. Pediatr. 21, 225-230.

2 Shakeri, H., Hadaegh, H., Abedi, F., Tajabadi-Ebrahimi,
M., Mazroii, N., Ghandi, Y., Asemi, Z., 2014. 
Consumption of symbiotic bread decreases triacylglycerol 
and VLDL levels while increasing HDL levels in serum from 
patients with type-2 diabetes. Lipids 49, 695-701.

3 Fujimori, S., Gudis, K., Mitsui, K., Seo, T., Yonezawa,
M., Tanaka, S., Tatsuguchi, A., Sakamoto, C., 2009. 
A randomized controlled trial on the efficacy of symbiotic versus probiotic or prebiotic treatment 
to improve the quality of life in patents with ulcerative colitis. Nutrition 
Burbank, Los Angeles County, Calif.) 25, 520-525.  Smid 2016

4 Ipar, N., Aydogdu, S.D., Yildirim, G.K., Inal, M.,
Gies, I., Vandenplas, Y., Dinleyici, E. 2015. 
Effects of symbiotic on anthropometry, lipid profile and oxidative stress in obese children. 
Beneficial Microb. 6, 775-782.

5  Hamer, H.M.,
Jonkers, D., Venema, K., Vanhoutvin, S. Troost, F.J., Brummer, R.J., 2008. 
Review article: the role of butyrate on clonic function. Aliment. Pharmacol. Ther. 27, 104-119.

6 Blatchford P., Stoklosinski, H.m Eady, S., Wallace, A.,
Butts, C., Gearry, R., Gibson, G., Ansell, J., 2017. 
Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally 
constipated individuals: a randomized controlled human trial. 
J. Nutr. Sci. 6e52-e52.

7 Furusawa, Y., Obata, Y., Fukuda, S., Endo, T.A.,
Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T.,Takahashi, M., Fukuda, N.N., 
Murakami, S., Miyauchi, E., ino, S., Atarashi, K.,Onawa, S., Fujimura, Y., Lockett, T., Clarke, J.M., 
Topping, D.L., Tomita, M.,Hori, S., Ohara, O., Morita, T., Koseki, H., Kikuchi, J., Honda, K., Hase, K.,
Ohno, H.,  2013;  
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. 
Nature 504, 446-450.

8 Furet, J.P., Kong, L.C., Tap, J., Poitou, C.,Basdevant, A., Bouillot, J.L., Mariat, D., Corthier, G., 
Dore, J., Henegar, C.,
Rizkalla, S., Clement, K., 2010. 
Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with 
metabolic and low-grade inflammation markers. 
Diabetes 59, 3049-3057.

9 Gonzalez-Sarrias, A., Romo-Vaquero, M.,Garcia-Villalba, R., Cortes-Martin, A., Selma, M.V., Espin, J.C., 
2018. 
The endotoxemia marker lipopolysaccharide-binding protein is reduced in overweight-obese subjects consuming 
pomegranate extract by modulating the gut microbiota: 
a randomized clinical trial. 
Mol. Nutr. Food Res. 62, e1800160.

PreBiotics

are non-digestible fibers that feed the bacteria living in your gut.

However, most prebiotics on the market can feed both harmful and beneficial gut bacteria. As you can see, this is not a good option if you already have an imbalance of the good and bad guys, which is called dysbiosis. You don’t want more of the bad guys; you want more of the good guys.

When you feed the bad bacteria, you can experience or even exacerbate digestive issues like gas, constipation, diarrhea, and / or cramping.

The population of the beneficial bacteria can be easily diminished by

  • Antibiotics
  • Stress
  • Diet
  • Glyphosate
  • and other environmental toxins that enter our body through the water we drink, the air we breath.

You can purchase MegaPrebiotic here

What if you could count on a prebiotic that feeds

ONLY

the good guys?

Microbiome Labs has developed a prebiotic that only feeds beneficial bacteria. Those keystone bacteria are Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bifidobacteria

Akkermansia Muciniphila

plays an important role in metabolism and has been shown to promote fat loss. Low levels of A. muciniphila have been associated with obesity, diabetes, liver disease, cardiometabolic diseases, and low-grade inflammation.**

Faecalibacterium Prausnitzii

can increase the production of butyrate, a short-chain fatty acid that can relieve intestinal inflammation. Low levels of F. prausnitzii have been associated with irritable bowel syndrome, inflammatory bowel diseases (IBD) like Crohn’s disease and ulcerative colitis, celiac disease, and chronic constipation.**

Bifidobacteria

can also increase butyrate production and promote lean body mass. Low levels of Bifidobacteria have been associated with obesity, diabetes, celiac disease, allergic asthma, dermatitis, IBD, chronic fatigue syndrome, and psoriasis.**

Increasing populations of these protective bacteria is an integral part of reinforcing a healthy gut microbiome. Studies have shown that a more diverse gut microbiome is associated with a stronger immune system and a decreased risk for chronic illness.**

**These Statements have not been evaluated by the Food and Drug Administration (FDA)

Introducing:

Prebiotic MegaPrebiotic

is a cutting-edge Precision Prebiotic™ supplement made up of

  • clinically-tested, non-digestible
  • Oligosaccharides that can increase microbial diversity and selectively feed beneficial keystone bacteria like Akkermansia muciniphila, Faecalibacterium prausnitzii, Bifidobacteria.

The oligosaccharides are derived from

  • non-GMO green and gold kiwi fruit,
  • non-GMO corn cob, and
  • rBST-free cow’s milk  (rBST: recombinant Bovine Somatotrophin is a growth hormone).

The findings of these oligosaccharide studies are quite impressive and have shown that Akkermansia muciniphila population increases by 8,000% in 5 weeks, F. prausnitzii by 100% in 4 weeks, Bifido by 10% in 6 weeks.

Increasing populations of these protective bacteria is an integral part of reinforcing a healthy gut microbiome. Studies have shown that a more diverse gut microbiome is associated with a stronger immune system and a decreased risk for chronic illness.

 Prebiotic, Megaprebiotic

MegaPreBiotic™ REINFORCES the beneficial microbial changes created by MegaSporeBiotic™ to promote a strong and diverse microbiome.**

 

MegaPreBiotic   Dosing Instructions

Start with ½ scoop daily for one week, then increase to 1 scoop daily with or without food, or as directed by your healthcare practitioner.

Mix into 16 oz of cold water or liquid of your choice.

For more information on gut health you may be interested in the article I wrote a while back on the Consequences of Leaky Gut, which you can read here:

and Triggers for an Autoimmune Disease

1) Blatchford P, Stoklosinski H, Eady S, et al. Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial. J Nutr Sci. 2017; 6: e52.

2) Everard A, Lazarevic V, Derrien M, et al. Responses of Gut Microbiota and Glucose and Lipid Metabolism to Prebiotics in Genetic Obese and Diet-Induced Leptin-Resistant Mice. Diabetes. 2011 Nov; 60(11): 2775–2786.

3) Yang J, Summanen PH, Henning SM, et al. Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study. Front Physiol. 2015; 6: 216.


Consequences of Leaky Gut

Lеаkу gut syndrome, also called Increased Gut Permeability, a diѕоrdеr саuѕеd by thе increased lеаkinеѕѕ оf intеѕtinаl mucosal mеmbrаnе, can have ѕоmе serious consequences if lеft unattended. Physicians think that treatment орtiоnѕ аrе diverse and limited in efficiency. They also think that there is ѕtill ѕоmе advantage tо соntrоlling or mаnаging thiѕ gаѕtrоintеѕtinаl problem whеn it comes tо рrеvеnting complications lаtеr оn.

What sticks out are the words “limited efficiency” and “controlling or managing” this problem. My personal experience shows leaky gut, which lead to the development of the autoimmune immune disease Hashimoto Thyroiditis, and severe food sensitivities, can be healed. After eliminating the foods my body was reacting to, especially eggs, eradicating pathogens, implementing meditation, using herbal supplements and spore biotics to support my bodies ability to heal the gut, I can report that I do NOT have any GI problems anymore. But back to the consequences of leaky gut.

Autоimmunе Diseases Due Tо Leaky Gut

Autоimmunе disorders occur whеn thе bоdу’ѕ immunе system (or ‘роliсеmаn сеllѕ’) turn аgаinѕt itѕ оwn hеаlthу tiѕѕuе, mistakenly thinking thеу аrе harmful раthоgеnѕ or fоrеign protein nееding еliminаtiоn. The result iѕ that thе bоdу’ѕ оwn рrоtесtivе mесhаniѕm turns аgаinѕt itѕеlf, creating havoc and can cause damage in all kinds of tissues.

Thеrе are a whоlе range оf diѕеаѕеѕ thаt fall under thiѕ саtеgоrу оf autoimmune diѕоrdеrѕ inсluding luрuѕ, rhеumаtоid arthritis, mixed соnnесtivе tiѕѕuе disease, Crоhn’ѕ disease and еvеn ѕоmе forms оf аrthritiѕ аnd diabetes.

Thе importance оf thе intestinal system in provoking and еxасеrbаting thеѕе autoimmune соnditiоnѕ has bееn rесоgnizеd lаtеlу аnd рhуѕiсiаnѕ treating раtiеntѕ with thеѕе diѕоrdеrѕ аrе bеginning tо take note of the role thаt Leaky Gut Sуndrоmе рlауѕ in it.

Othеr Diѕеаѕеѕ Cаuѕеd Bу Leaky Gut

Leaky gut syndrome саn со-еxiѕt аlоng with оthеr hеаlth рrоblеmѕ, many оf whiсh аrе wоrѕеnеd without repairing a leaky gut. A fеw оf thеѕе аѕѕосiаtеd diѕеаѕеѕ inсludе:

  • Eczema, рѕоriаѕiѕ аnd several other dermatologic conditions

  • Pancreas dеfiсiеnсу lеаding to mаlаbѕоrрtiоn and diаbеtеѕ

  • Fungal аnd yeast infесtiоnѕ such аѕ candida infestation

  • Mаlnutritiоn ѕесоndаrу to failure of absorption оf nutriеntѕ

  • Sеnѕitivitу tо ѕеvеrаl chemicals and аdditivеѕ саuѕing аllеrgiеѕ

  • Fаtiguе, tiredness, аnd a fаilurе tо thrive in сhildrеn

  • Frequеnt hеаdасhеѕ аnd inаbilitу tо concentrate on wоrk

  • Lоѕѕ оf memory and easy fоrgеtfulnеѕѕ аrе соnѕеԛuеnсеѕ

  • Bowel disturbances lеаding tо diаrrhеа аnd irrеgulаr hаbitѕ

  • Anxiety

Whеn Lеаkу Gut Syndrome affects сhildrеn, thе рrоblеmѕ аrе соmроundеd bу the requirеmеnt fоr highеr lеvеlѕ of nutriеntѕ in diet fоr уоungѕtеrѕ аѕ wеll as the lоng tеrm consequences оf сhrоniс infесtiоnѕ аnd malnutrition. Vассinаtiоn has led tо a similar syndrome like lеаkу gut in some сhildrеn.

Livеr Diѕоrdеrѕ Rеѕulting From Leaky Gut

With thе liver bеing thе firѕt mаjоr barrier tо tоxinѕ thаt еntеr thе blооd ѕtrеаm thrоugh leaky gut mеmbrаnеѕ, it is nоt ѕurрriѕing that thе liver iѕ affected аt ѕоmе stage or the оthеr in реорlе with leaky gut ѕуndrоmе.

Sоmе tоxinѕ mау еѕсаре thе ѕсаvеnging еffесt of thе liver, аnd еntеr thе general circulation саuѕing harm in ѕеvеrаl tissues. But most оf thеm gеt trарреd by thе livеr, whеrе thеу are nеutrаlizеd аnd еxсrеtеd in bilе. Hоwеvеr, this increased lоаd on thе livеr can ѕоmеtimеѕ lеаd tо mаlfunсtiоn, оr even frank livеr fаilurе, thоugh these аrе extreme соmрliсаtiоnѕ that hарреn only in a very tinу minority of ѕuffеrеrѕ.

See my article on liver detoxification here.

What could pass the gut lining and enter the hepatic portal vein?

  • Toxins, environmental; from bacteria and viruses
  • Larger, partially digested food particles
  • Histamine
  • Zonulin, Bacteria secret toxins and can alter tight junctions.

The increased gut permeability happens at the microvilli, which are finger like structures and single layer of cells. The microvilli reach into the gut and have the job to let the nutrients and vitamins, extracted from digested food, into the blood stream which leads to the hepatic portal vein. This vein brings the nutrients, vitamins, and toxins into the liver for detoxification.

In a healthy gut the single cell layer of the microvilli are held together with proteins called tight junctions. When digested food reaches the microvilli, the tight junctions loosen up just so much that the nutrients can get into the blood stream. Zonulin regulate the opening and closing of the tight junctions.

The question then is How can we prevent and heal a Leaky Gut?

  • Identify and Remove inflammatory foods from your diet

MRT food sensitivity test, IgG, IgM, IgE antigen blood test

      • Eat organic foods if possible to avoid chemicals. At least wash fruits and vegetables with water and vinegar. Peal fruits.
      • Drink enough water to prevent dehydration. Water is necessary for phase II detoxification.
      • Identify and Remove pathogens in the gut, such as parasites using a stool pathogen test. Blood tests for virus antibodies. CBC with diff to check if the immune system is overactive.
      • A better option would be to restore gut function with the 3 Step Gut Restoration Program.
      • You also can listen to my Youtube video on the 3 Step Gut Restoration Program

    • Reduce Stress: don’t over commit, learning to say NO can be very important.
    • Reduce EMF exposure; turn wifi off at night (Check out my Youtube channel on this subject)
    • Don’t use a cell phone and/or computer at night before you go to bed. The blue light emitted by the screen of those devices prohibit melatonin production.
    • Sleep in a dark, cool room

If you have any questions, can contact me.

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Reference:


Zonulin signaling http://en.wikipedia.org/wiki/Zonulin

The gastrointestinal tract microbiome, probiotics, and mood.   Vitetta L1, Bambling M, Alford H.

Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis.

Lin R1,Zhou L1,Zhang J1,Wang B1.

Arthritis susceptibility and the gut microbiome. Taneja V1.

Leaky gut and autoimmune diseases. Fasano A1.

Gut permeability is related to body weight, fatty liver disease, and insulin resistance in obese individuals undergoing weight reduction.    Damms-Machado A1, Louis S1

Abnormal Barrier Function in Gastrointestinal Disorders.   Farré R1,2, Vicario M3,4,5.

Candida

Candida – Can you free yourself ?

Candida overgrowth is not recognized as a real health issue; therefore, most physicians don’t test for it.

However, you are experiencing symptoms such as:

  • Bloating
  • Brain fog, difficulty concentrating and/or focusing
  • Fatigue, tired all the time
  • Sugar cravings
  • Sinus congestion
  • Headaches
  • Skin irritations, acne, rashes
  • Depression, mood swings, even anxiety
  • Vaginal itching

Everyone has Candida yeast in the gut, mouth and vagina. Candida is not all bad, as it helps with digestion and nutrient absorption.  Other gut bacteria need to be kept in check, otherwise we end up with Candida overgrowth and once we have reached this point, we develop symptoms.

Causes of Candida overgrowth

Candida is called an opportunistic organism, which means it will get out of control like a child or teenager left alone at home. We need adults at home, which are other good bacteria to keep Candida in check. So, if there is an imbalance between the good and bad bacteria in the gut, called Dysbiosis, Candida will do what it does best; multiply.

This brings us to the next question:

What are the causes of Dysbiosis of the microflora?

  • Toxins from the environment
  • Heavy metals
  • Stress, lifestyle stressors, not enough sleep, poor diet high in sugar and refined carbohydrates
  • Antibiotics
  • Anti-inflammatory drugs
  • Adrenal issues, too much or too little cortisol
  • Parasite infection

How to get rid of Candida?

Well, we never can get rid of Candida, but we can get rid of Candida overgrowth.

As a Functional Diagnostic Practitioner, I look at underlying causes of symptoms. In the case of Candida overgrowth, I know that it is not the problem, but it is the result of the underlying problem.

Most of the time, the immune system is compromised and bacterial dysbiosis in the gut, due to a lack of supervision so to speak, creates the opportunity for Candida to grow uncontrollably.

  • Candida lives on sugar and refined carbohydrates. In order to starve it, food items that contain those sugars need to be eliminated.
  • In regard to the dysbiosis, we need to heal the gut, which includes balancing the gut flora.
  • I mentioned stressors as the cause of Candida overgrowth; therefore, we need to look at those and eliminate as many as possible.

Takeaway: if you think you have Candida overgrowth and you follow one of those protocols to kill Candida offered online, it may not work for you in the long run.

My approach as a Functional Diagnostic Practitioner:

  • Starving Candida with a sugar and starch free diet.
  • Eating “Real” Foods such as grass fed beef, eggs from free roaming chicken not fed with grains, replenish minerals and vitamins and healthy fats.
  • Stress reduction: Identifying inside stressors such as parasites and bacterial dysbiosis and correcting the problem with the help of herbal supplements. Identifying external stressors such as the influence of a negative person in one’s life, environmental toxins.
  • Sleep hygiene. Going to bed around 10pm.
  • Exercise: not everyone can go to the gym 3-5 times a week. Some are just too weak to even walk around the block. Whatever exercise you can perform is the one you could start out with.
  • Biofilm disrupter: this is huge. All bacteria in the gut or sinuses block the immune system from reaching it by creating a biofilm. Most of the time, biofilms are several layers thick and are hard to break open.
  • Identifying pathogens and getting rid of those with herbal supplements.
  • Supplementation with antifungals to kill Candida.
  • Gut healing supplements: they repair the mucosal barrier in the gut lining
  • Probiotics play a big role in balancing the intestinal flora; they even help to digest food and produce nutrients.
  • RestorFlora contains S.boulardii  or
  • MegaMycoBalance

This holistic approach to restoring balance and function in your entire body is the principle that I work with. It may not always be easy, but it is the best option to support the body in healing itself.

Contact me if you would like a free consultation

Inflammation

is actually a positive reaction of the body. In the case of injuries the acute inflammation helps to protect damaged regions and starts the repair.

An acute inflammation lasts only days or a couple of weeks. If the inflammation lasts longer then we talk about a chronic inflammation.
Chronic inflammation is the result of injury, auto immune processes or infections.
Leukocytes involved in the process of a chronic inflammation are monocytes and macrophages.
The problem is the production of pro-inflammatory mediators which cause tissue damage.
If we look further into the immune system involvement then we find CD4 classified immune cells. They produce cytokines, which are chemical messengers.
Other immune cells involved in the immune system response are Thymus Helper Cells for short Th. There are several branches of TH cells like the TH1, TH2, TH17 and Treg (regulatory T cells).
If you have Hashimoto’s then you probably know about TH1 or 2 dominance. TH17 pathway is often times overlooked, but is as important as the other pathways.
TH1 cells are activated in the case of microorganisms while TH2 cells protect against parasitic infections.
Interesting to know for women is probably the fact that during a pregnancy the immune system dominates shifts toward TH2.
Therefore the babies are most likely born with a th2 dominance. Once they are exposed to germs, microorganisms then the body develops the immune system and the body will balance TH1/2.
So, what is the TH17 pathway? It plays a major role in the Gastro intestinal tract. Th17 pathway will attract neutrophils and promote inflammation. Neutrophils are white blood cells and are involved in the innate immune system / meaning it is the first line of defense, acting in the case of infections but it will not cause a long lasting protective immunity in the host.
Treg cells (Regulatory T cells or suppressor cells) limit chronic inflammation by suppressing the activation of the immune system and are very important in preventing autoimmunity.

or contact me if you would like to book a free 20 minute Health Consultation.