Anxiety and Mood Swings – Thyroid or Pyroluria


What You Should Know about Pyroluria, Anxiety, and Mood Swings

What exactly is Pyroluria? Well, Pyroluria which is also called Kryptopyroluria or Pyrrole disorder, is a by-products of hemoglobin synthesis. Pyroluria is a condition whereby more than the normal amount of Pyrrole molecules are produced. Pyrroles are excreted through the urine, which makes testing for Pyroluria very easy. There are some symptoms of Pyroluria you may want to look at and these include:

  • Depression
  • Anxiety
  • Mood swings
  • Hyperactivity
  • Noise sensitivity
  • Sensitive to bright light
  • Poor stress adaptation
  • Obsessive-compulsive behavior
  • White spot on fingernails
  • Insomnia
  • No dream recall
  • Loss of appetite in the mornings
  • Poor memory
  • Brain fog
  • Dry skin
  • Suffer often from infections

As noted above, Pyrroles are excreted through the urine and because Pyrroles bind to zinc and vitamin B6, both are also excreted through urine. This leads to a deficiency of both zinc and vitamin B6.

When we look at the role of vitamin B6 and zinc, we can find that they are both important cofactors in methylation processes.

A higher incidence of Pyrrole disorder is found in individuals with the

  • Autism spectrum. It is also found in individuals with
  • Anxiety disorder,
  • Depression,
  • Obsessive-compulsive disorder,
  • Schizophrenia,
  • Bipolar disorder,
  • Aspergers, and
  • ADHD.

The severity of the symptoms of Pyroluria depends on different factors and can range from very mild to very severe. It is unfortunate that physicians usually do not test their patients for Pyroluria simply because they either do not know about it or they do not believe in it. Instead their patients receive a prescription for antidepressants. Yet, the underlying cause has not been addressed in any way and the suffering of patients continues needlessly. Today, numerous studies have been conducted on this condition and can be easily accessed online.

We need to be cautious when we start supplementing with zinc simply because it can lead to low copper. We need to be mindful when we start taking any mineral because it can influence other minerals and can cause a mineral imbalance. When this happens, we end up with even more problems than before.

In addition, if you are feeling worse on fish oil, then you should consider getting tested for Pyroluria. Vitamin B6 as P5P and Zinc supplementation can be very helpful, but they need to be monitored carefully in conjunction with symptom changes.


 Vitamin B6 nutritional status of a psychiatric outpatient population

A Sohler, CC Pfeiffer - J Orthomolec Psychiatr, 1982 -

The discovery of kryptopyrrole and its importance in diagnosis of biochemical imbalances in schizophrenia and in criminal behavior

A Hoffer - Children, 1995 -

Pharmacol Biochem Behav.1975 Mar-Apr;3(2):243-50.

Neurological and behavioral toxicity of kryptopyrrole in the rat.

Walker JL. 

Identification of kryptopyrrole in human urine and its relation to psychosis.

Irvine DG, Bayne W, Miyashita H, Majer JR.

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The information provided on this website is not meant to substitute professional medical advice. Consult your health care provider in regard to supplementation, especially if you are on any kind of medication.